Commissioned synthesis
What we aspire for is the eco-friendly chemical technology.
We are under an operating agreement with a visitor, perform contracted research, development and manufacture of new materials.
Content of trust
A wide range of commissioning synthesis from gram weights to ton weights.
No capital affiliation with major chemical or pharmaceutical companies, which allow us to comply strictly with the confidentially.
Proposal of literature researches and synthetic schema, and provision of synthesis manuals and synthetic compounds.
Prompt raw material arrangement from our accumulated domestic and informational information.
Provision of synthetic technologies such as medicine, various intermediates, various electronic materials, functional fine ceramics materials and functional Pigments. Structure of GMP·corresponding production system of active pharmaceutical ingredients and investigational new drugs. One-time synthesis and continuous production are possible.
Production technology
● Halogenation (chlorination, bromination)
Nuclear halogenation, side-chain halogenation, aliphatic halogenation, acid halide
●Friedel-Crafts reaction
●Grignard reaction
●Acylating reaction
●Amino-acid derivative
Peptide Synthesis, z(benzyloxycarbonyl)transformation, tert·butoxycarbonyl transformation, active-ester transformation and others.
● Low-temperature reaction
(possible down to 80 degrees C below zero)
●Other various synthesis achievements
Quality assurance system
It is structured by Quality Assurance (QA) Department controlling the whole company and Quality Control (QC)
Section of each plant is an organization of the QA Dept.
Our company obtained the certification of ISO9001 in 1998 for the whole company including the factories, sales branches and research institutes and in December 2007 we completed the third review for renewal of ISO9001 version 2000.
The quality of all our products including commissioned synthetic compounds is controlled by ISO9001.
Proposals of lab-scale, literature researches, synthetic schema.
Production of active pharmaceutical ingredients and food additives by mass production of chemical products and GMP-corresponding facility.
| Main facilities |
| Reaction tank(GL) |
10,000L |
12units |
| Reaction tank(GL) |
20,000L |
1units |
| Reaction tank(GL) |
1,000L |
3units |
| Receiver(GL)
|
800～15,000L |
16units |
Reaction tank(SUS316)
※first class pressure vessel high temperature(250℃) |
10,000L |
2units |
| Receiver(SUS316) |
8,000L |
2units |
| Reaction tank(SUS316) |
10,000L |
1units |
| Condenser(SUS) |
4㎡～15㎡ |
7units |
| Condenser(Carvent) |
5㎡～30㎡ |
16units |
| Filtration(SUS) |
1㎡～10㎡ |
4units |
| Centrifuge |
48in. |
3units |
| 60in. |
1units |
| Dryer Conical dryer(GL) |
150L |
1units |
| 4,000L |
3units |
| 6,000L |
1units |
| Clean room |
class 100,000 |
2rooms |
| Analytics |
| Gas chromatography
|
4 |
| Liquid chromatography
|
9 |
| Fourier transform infrared spectrophotometer
|
1 |
| Spectrophotometer
|
1 |
| Viscometer
|
1 |
| Viscometer B-type
|
1 |
| pH meter
|
1 |
| NMR Particle(0.02-700μm)
|
1 |
| Automated melting point system
|
1 |
| Density meters and specific meters
|
1 |
| Automatic titrator
|
1 |
| Stability chambers
|
3 |
| Karl Fischer
|
2 |
| Electric furnace |
1 |
One-time synthesis and continuous production are possible.
Consideration for the scale-up to connect to Okuma Plant.
Production of active pharmaceutical ingredients and investigational new drugs.
| Production Department |
| Production technology Section |
| Lab scale-500L reaction scale
|
| 1,000L-4,000L reaction scale
|
| Production by multi facilities
|
| Scale-up consideration by pilot facility
|
| GMP facility
|
| Main facilities |
| Reaction tank(GL) |
30～4,000L |
37units |
| Reaction tank(SUS)
|
30～1,500L |
8units |
| Reaction tank(Hastelloy)
|
150～1,000L |
3units |
| Mixing tank(plastic)
|
many |
| Centrifuge(SUS)
|
24～42in. |
7units |
| Filtration
|
7units |
| Dryer |
Conical dryyer(GL) |
650～850L |
2units |
| Shelf type(SUS)
|
2units |
| Clean room class 100,000
|
2rooms |
| Clean booth, clean bench
|
many |
| Analytics |
| Gas chromatography(including capillary-use-only)
|
7 |
| Liquied chromatography
|
10 |
| Ion chromatography
|
5 |
| Gas chromatography mass spectroscope
|
1 |
| LC-MS
|
1 |
| Fourier transform infrared spectrophotometer
|
1 |
| Spectrophotometer
|
1 |
| Atomic absorption photometer(frame, non-frame)
|
2 |
| ICP mass spectroscope
|
1 |
| ICP emission spectrophotometer
|
1 |
| Polarimeter
|
1 |
| NMR(300MHz)
|
1 |
| Particle size distribution measuring instrument(Micro Truck)
|
1 |
| Surface area measuring instrument
|
1 |
| Karl Fischer(volume, coulometry, moisture vaporization instrument)
|
3 |
| Automatic titrator
|
2 |
| Viscometer(E-type, B-type)
|
3 |
| Particle counter
|
1 |
| Automated melting point system
|
1 |
| pH meter
|
2 |
| Supersensitive pH meter
|
2 |
| Gel Permeation Chromatography |
2 |